VS-01™

Vaginal Synbiotic

448 Reviews

The first vaginal probiotic suppository clinically validated to establish an optimal vaginal microbiome dominated by L. crispatus.

4.7 out of 5 stars · 448 reviews

Non-Irritating
Non-Toxic
No PFAS
No Preservatives or Parabens
No BPAs
No Phthalates
Vegan
No Artificial Fragrances or Dyes

Benefits

90% Of participants established an optimal vaginal microbiome dominated by L. crispatus
10x Increase of L. crispatus abundance in participants within 21 days of use
100% Of participants maintained an optimal vaginal pH

How to Use

Gently press a VS-01™ vaginal tablet out of the aluminum pack into washed hands before each use.
Place the VS-01™ vaginal tablet securely into an applicator.
Insert into your vagina, and push the inner tube towards you to release (just like a tampon).
After releasing, remove and dispose of the applicator. Please note that each applicator is a Class I Medical Device and cannot be recycled.

Ingredients

Probiotic Ecology: L. crispatus LUCA103™, L. crispatus LUCA011™, L. crispatus LUCA009™. Nutrient Complex: Maltose, Calcium Lactate, Glutamine, DiBasic Magnesium Citrate, Cystine. Other Ingredients: Plant-Derived Cellulose, Magnesium Stearate, Hydroxypropyl Methylcellulose (HPMC). Tested for biocompatibility with the vaginal environment, 14 classes of allergens, 500+ contaminants, and osmolality.

Subscription Options

2 Month Starter Kit — $39.99/month thereafter

Hero

H1: VS-01™ Vaginal Synbiotic | 448 Reviews. Subtitle: The first vaginal probiotic suppository clinically validated to establish an optimal vaginal microbiome dominated by L. crispatus. Price: $99.00. '2 Month Starter Kit' | '$39.99/month thereafter'. Button: Join the Waitlist. Bullets: Free US shipping. | Reschedule or cancel any time. | 30 day risk-free guarantee. | HSA / FSA eligible.

Day-to-day life can disrupt the balance of your vaginal microbiome, depleting its critical super defender— Lactobacillus crispatus.

What Is the Vaginal Microbiome?

Comprised of bacteria, fungi, and viruses, this ecosystem is critical to your gynecological, urogenital, and reproductive health. Unlike the diverse gut microbiome, the vaginal microbiome thrives when dominated by one bacterium: L. crispatus. However, many lack this abundance, leading to susceptibility to disruptions and imbalances. H3: 9 out of 10 women have an unstable vaginal microbiome.1 Chart label: Proportion of Subjects by Stability — % of Subjects. Figure 1. The proportion of participants who underwent daily sampling and had a stability score equal to or greater than 90%. Only 10% of participants exhibited a stable vaginal microbiome. Stability score was defined as the proportion of days in which an individual had an L. crispatus dominated microbiome. Citations: 1 Seed Health R+D (2024) Disruption and Stability of the Vaginal Microbiome: A Data-Driven Approach [White Paper](https://seed.com/cultured/research-analysis-disruption-and-stability-of-the-vaginal-microbiome/) Seed Health.

BUILT ON DR. JACQUES RAVEL'S RESEARCH

VS-01™ emerged from the discovery that specific strains of L. crispatus defend the vaginal microbiome from pH disruptions and imbalances. Fig 1. Our three proprietary L. crispatus strains in VS-01™. Sub-heading: A Victory for Vaginal Health — Propelled by the unmet needs in women's health, we partnered with Dr. Jacques Ravel to transform over two decades of vaginal microbiome sampling and metagenomic research into real world impact. Jacques Ravel, PhD — Seed Scientific Advisor; Founder, LUCA Platform. Timeline: 2006 — Dr. Ravel receives the first-ever NIH grant dedicated to studying the vaginal microbiome. | 2009 — Dr Ravel initiates the vaginal program under the NIH's Human Microbiome Project (HMP) to define what constitutes a healthy vaginal microbiome. | 2012 — Dr. Ravel publishes a landmark study1 demonstrating that the most stable and optimal vaginal microbiome is dominated by one bacterium: Lactobacillus crispatus. | 2016-Present — Seed partners with Dr. Ravel to launch LUCA Biologics, a vaginal microbiome platform targeting the vaginal microbiome for unmet needs in gynecological and reproductive health. | 2020 — Dr. Ravel publishes the largest metagenomic gene catalog2 of the vaginal microbiome to date. | 2023 — Dr. Ravel publishes the most comprehensive metagenomic analysis3 characterizing the vaginal microbiome into 27 community state types, including 6 sub-types of L. crispatus. | Today — VS-01™ is the first innovation to emerge from Seed's vaginal microbiome platform, setting a new paradigm of innovation, empowerment, and care. CITATIONS: 1 Gajer, P., Brotman, R. M., Bai, G., Sakamoto, J., Schütte, U. M., Zhong, X., Koenig, S. S., Fu, L., Ma, Z. S., Zhou, X., Abdo, Z., Forney, L. J., & Ravel, J. (2012). Temporal dynamics of the human vaginal microbiota. Science Translational Medicine, 4(132), 132ra52. https://doi.org/10.1126/scitranslmed.3003605 | 2 Brouillett, Monique. Scientific American. 2020. Decoding the Vaginal Microbiome. Retrieved May 4, 2024, from https://www.scientificamerican.com/article/decoding-the-vaginal-microbiome/ | 3 Holm, J.B., France, M.T., Gajer, P. et al. Integrating compositional and functional content to describe vaginal microbiomes in health and disease. Microbiome 11, 259 (2023). https://doi.org/10.1186/s40168-023-01692-x

An Evolution in Vaginal Health — VS-01™ is the first and only vaginal synbiotic clinically validated to optimize your vaginal microbiome with three proprietary L. crispatus probiotic strains.

Tabs: Probiotic Ecology | Prebiotic Complex | SMART Tablet™ Delivery. Probiotic Ecology: Three proprietary live L. crispatus probiotic strains selected for their genomic diversity and strengthening of vaginal stability and resilience: LUCA103™, LUCA011™, LUCA009™. Link: Explore Our Formulation

Formulation

Probiotic Ecology — L. crispatus LUCA103™, L. crispatus LUCA011™, L. crispatus LUCA009™. Nutrient Complex — Maltose, Calcium Lactate, Glutamine, DiBasic Magnesium Citrate, Cystine. Other Ingredients — Plant-Derived Cellulose, Magnesium Stearate, Hydroxypropyl Methylcellulose (HPMC). Tested for biocompatibility with the vaginal environment, 14 classes of allergens, 500+ contaminants, and osmolality. Icon labels: Non-Irritating | Non-Toxic | No PFAS | No Preservatives or Parabens | No BPAs | No Phthalates | Vegan | No Artificial Fragrances or Dyes. Note: VS-01™ requires your body's natural lubrication for proper dissolution, and therefore may not be as effective among women experiencing significant vaginal dryness.

CLINICALLY VALIDATED EFFICACY

Results from a randomized, double-blind, placebo-controlled clinical trial: 90% Of participants established an optimal vaginal microbiome dominated by L. crispatus | 10x Increase of L. crispatus abundance in participants within 21 days of use | 100% Of participants maintained an optimal vaginal pH. Link: Our Clinical Research

Our Clinical Research

In our first randomized, double-blind, placebo-controlled clinical trial, VS-01™ converted 90% of participants to an optimal vaginal microbiome within 21 days and was superior to both a leading oral probiotic for vaginal health and placebo1. Figure 1. The proportion of participants with a non-optimal baseline vaginal microbiome who converted to an optimal vaginal microbiome. Figure 2. Change in the average relative abundance of L. crispatus in participants with a non-optimal baseline vaginal microbiome. CITATIONS: 1 Ravel, J., Simmons, S., Greenwood Jawa, E., Gottfried, S., Greene, M., Kellogg-Spadt, S., Gevers, D., Harper, D. IDSOG Annual Meeting 2024.

Using VS-01™ — Address the Source, Not the Symptoms

Finally, a sustainable approach to address the root cause of imbalances and sustainably defend against daily disruptions. Sub-block: 2 Month Starter Kit — Month 1 Reset: Your first-month reset to rapidly establish an optimal vaginal microbiome. Month 2+ Sustain: The two-tablet monthly protocol that maintains stability and protects against pH disruptors. Testimonials: "Since starting VS-01™, I'm not as worried about the potential of disrupting my vagina." | "I noticed results in a few weeks of use, with more significant results after 1 month of use." | "For me, it was more about not noticing things that were common and disruptive to my day. I was having to put a lot of unnecessary attention to those things before." | "Sometime during the first week, I realized I was no longer aware of my vagina. Which sounds funny, but not noticing my vagina was actually amazing."

A New Standard of Safety

The vagina is one of the most delicate ecosystems of the human body, yet vaginal health products are not subject to rigorous safety testing. We set out to close the gap with superior testing and safety checks. Tested For: Biocompatibility with the vaginal environment | 14 classes of allergens, including gluten, nuts, and soy | 500+ contaminants (chemical residues and heavy metals) | Osmolality (typically only tested for in lubricants). Non-Toxic + Non-Irritating: Non-disruptive to the vaginal mucosal barrier in a cruelty-free, FDA-recognized tissue model | No histological changes or cellular tissue damage | No adverse toxicity outcomes in gold-standard human clinical trial. Icon labels: Non-Irritating | Non-Toxic | No PFAS | No Preservatives or Parabens | No BPAs | No Phthalates | No Artificial Fragrances or Dyes | Vegan.

From Leading Providers

Erica Chidi — Author, Health Educator and Entrepreneur: "VS-01™ represents a tectonic shift in women's health. It's the missing link in how women can protect and maintain their vaginal health, backed by rigorous science." | Jane van Dis, MD — Assistant Professor of Obstetrics & Gynecology, University of Rochester: "VS-01™ offers a way out of the endless cycle of symptom management, providing a means to maintain the health of the vaginal microbiome against everyday disruptors. This is more than a product; it's a paradigm shift in how we think about and care for vaginal health."

The VS-01™ Difference

Many existing products and certain prescriptions for vaginal health only target the symptoms and can disrupt the vaginal microbiome. VS-01™ offers a new approach that outperforms on efficacy and safety. Comparison table columns: (blank) | VS-01™ | Leading Oral Probiotic for Vaginal Health | Certain Prescriptions. Rows: Establishes an optimal, resilient vaginal microbiome | Increases abundance of L. crispatus | Safely interacts directly with epithelial cells in the vagina. Link: View All

Expanding Impact and Access

Women's health has been neglected for far too long. Inadequate funding and research have stifled innovation and left critical gaps in care. While VS-01™ marks an exciting milestone in our effort to prioritize vaginal microbiome research and address the unmet needs of people with vaginas, we believe there is much more to be done when it comes to democratizing safe and effective care. Here are a few ways we're working to improve access: HSA / FSA Eligibility ... More programs and education are on the way. If you know of a nonprofit organization or healthcare provider interested in collaborating, email impact@seed.com. We recognize that the definition of women's health is evolving. To ensure inclusivity in our language, imagery, and marketing, we have partnered with the Eidos LGBTQ+ Health Initiative at the University of Pennsylvania (https://penneidos.org/).

Meet SciCare

Skip the searches—our team of experts is here to answer your questions about the vaginal microbiome, VS-01™, and beyond. Hi, I'm Jordie from SciCare. I'm happy to answer any of your VS-01™ questions. How can I help you?

Questions? We're here to guide you.

We keep a list of questions we get asked often on our FAQ page (https://help.seed.com/). FAQ: Q What is your 30 day risk-free guarantee? Do you accept returns? — A If for any reason you are not satisfied with your purchase, you may request a refund within 30 days of delivery of your first order. We'll refund you for the full cost of the product less shipping, VAT, and duties—no questions asked. Refunds apply to your first order only, not any subsequent shipments. For all subsequent shipments, you may reschedule or cancel at any time in your Account (https://seed.com/account). Kindly note that Sustainable Refill Program orders are considered final sale 30 days after delivery. | Q What does VS-01™ do? — A While most available solutions target only the symptoms in ways that further disturb the vagina, VS-01™ addresses the source—the vaginal microbiome. VS-01™ begins with an intensive first month Reset to rapidly establish an optimal vaginal microbiome and continues with monthly Sustain — the simple, two-tablet monthly protocol to maintain a stable vaginal microbiome and regulate pH. In a double-blind, randomized, placebo-controlled clinical trial, VS-01™ restored and maintained an optimal vaginal microbiome 10x more effectively than a leading oral vaginal probiotic, and 100% of participants experienced regulated vaginal pH. | Q How long should I take VS-01™ for? — A VS-01™ is designed for ongoing use to rapidly establish and then maintain a resilient vaginal microbiome less prone to disruptions from day-to-day life. VS-01™ is also rigorously third-party evaluated and verified safe for long-term use. | Q Who should take VS-01™? — A VS-01™ is recommended for individuals 18 and older seeking to restore and maintain an optimal vaginal microbiome. VS-01™ has been clinically studied among individuals 18-55 years old, and clinicians have used it through all adult ages. If you have any pre-existing conditions and are curious about incorporating VS-01™ into your routine, please consult with your health care provider. | Q Is VS-01™ safe? — A VS-01™ has a rigorous safety profile through clinical (in humans) and preclinical (in laboratory environments) testing. VS-01™ is extensively third-party evaluated for contaminants, heavy metals, impurities and all classes of allergens. It is formulated with gentle, non-irritating ingredients and tested for safety and vaginal biocompatibility using an FDA-recognized tissue model. | Q How do I use my HSA/FSA to pay? — A You can place an order online using your FSA or HSA card (as you would any other credit or debit card). We've taken all of the necessary steps on our end to ensure that you can use your FSA or HSA funds to purchase VS-01™. We also recommend consulting your provider to determine what documentation is required to have your claim approved, as many providers require a Letter of Medical Necessity (LMN) in addition to a receipt. | Q What does my subscription include? — A Your monthly subscription includes a 30-day supply of PDS-08®, each dose housed in biofilm sachets. Your first month's shipment is your Welcome Kit. It includes a refillable aluminum BacTrac™ container holding the first month's supply of PDS-08® as well as some reading materials. Each month, you will receive a 30-day supply of PDS-08®, which you can store in your refillable BacTrac™. | Q How do I use VS-01™? — A Menstruation is one of the most known day-to-day disruptors of the vaginal microbiome. VS-01™ is designed to work with your body's unique cycle by rapidly restoring your vaginal microbiome with an initial Reset, and then maintaining stability and regulated pH with monthly use. Gently press a VS-01™ vaginal tablet out of the aluminum pack into washed hands before each use. Place the VS-01™ vaginal tablet securely into an applicator. Insert into your vagina, and push the inner tube towards you to release (just like a tampon). After releasing, remove and dispose of the applicator. Please note that each applicator is a Class I Medical Device and cannot be recycled. | Q Can I be sexually active while using VS-01™? — A Yes—you can be sexually active while using VS-01™, though we recommend abstaining from sexual activity for 12 hours after inserting a tablet, to allow the tablet enough time to dissolve completely.

Member Reviews

4.7 out of 5 stars, based on 448 reviews. Breakdown: 5★ 364 | 4★ 46 | 3★ 20 | 2★ 9 | 1★ 9. Popular topics: smell, feel, packaging, issues, symptoms, improvement, results, difference. Sort by: Highest rating / Lowest rating / With media / Most recent / Verified purchase. Reviews: Heather D. 🇺🇸 (Verified Buyer, 08/14/26, 2/1) 'This has really helped with the reoccurring yeast infections I was having' | Katie N. 🇺🇸 (Verified Buyer, 07/08/26, 9/1) 'I like the three month sustain in one pack. Wouldn't change a thing about formula, would love to see more discounts especially if you buy a lot over time' | Star C. 🇺🇸 (Verified Buyer, 06/06/26, 1/2) 'Works well. Recommend it' | Erin L. 🇺🇸 (Verified Buyer, 05/04/26, 3/2) 'Love this product. Easy to use. Definitely has improved my overall vaginal health.' | Samantha F. 🇺🇸 (Verified Buyer, 04/28/26, 15/2) 'Using this for months along side diet changes and supplements has helped me beat chronic yeast infections!! TMI but my first few months using I'd see the yeast being expelled by the good bacteria. Now I no longer see that so I'm happy to say it's keeping me balanced!'

Sticky add-to-cart bar

VS-01™ Vaginal Synbiotic | Join the Waitlist

$99.00

30-day supply delivered monthly. Pause or cancel anytime.

30-day risk-free guarantee. Free US shipping.

Rapidly establishes a healthy vaginal microbiome dominated by L. crispatus—the vagina’s most protective bacteria.*

Bundle + Save 25%

Add DM-02® Daily Multivitamin to your routine and save on your first order.

$67.50 ~~$89.98~~

The DS-01® difference: Benefits that build over time

Results you can feel in as little as 7 days.*

7 Days
Reduces Bloating + Gas*
- Reduces rumbling in the gut
- Alleviates excess gas
- Lessens disruption from bloating**
2 Weeks
Supports Healthy Regularity*††
- Improves stool quality
- Reduces occasional constipation
- Makes pooping easier
4 Weeks
Smooths Skin Aging*††
- Supports skin appearance
- Reduces fine lines
- Reduces wrinkles
3 Months
6 Weeks + Whole Body Health*
- Promotes overall digestive quality of life
- Supports immune system balance††
- Increases micronutrient synthesis††